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Incident lesions had been identified inside fifteen sexually active women, plus step one highest-stages lesion and you can fourteen lowest-grade lesions

Potential risk factors included the total number of instances of vaginal intercourse (continuous variable), the number of new partners (0, 1, or >1), the frequency of condom use by partners (<5 percent, 5 to 49 percent, 50 to 99 percent, or 100 percent), the partner's circumcision status (circumcised, uncircumcised, or unknown), and the partner's number of previous partners (0, ?1, or unknown). The frequency of condom use was calculated by dividing the number of condoms used for vaginal intercourse by the number of instances of vaginal intercourse during the eight-month study period. If multiple new partners were reported during an eight-month period, the circumcision status and previous number of partners were summarized ( Table 1 ). The percentage of days that lacked diary entries was calculated to assess potential confounding created by missing data. The effect of the frequency of condom use was evaluated by multivariate analysis with the inclusion of other variables that were found to be significant (P<0.10) in univariate analyses. Similar analyses were performed to evaluate risk factors for high-risk types of HPV (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 73, and 82), 20,21 low-risk types (6, 11, 40, 42, 54, 55, 57, 61, 62, 64, 69, 70, 71, 72, 81, 83, 84, and CP6108), 20,21 and types 6, 11, 16, and 18 (which are included in quadrivalent vaccine trials 22 ). To evaluate whether the effect of condom use on the risk of HPV infection differed according to the location in the genital tract, similar analyses were performed to examine risk factors for incident cervical and vulvovaginal infections.

During the subanalyses, victims whoever lovers used condoms 100 % of the time was in fact split up into several categories on the basis of the answers in order to practical question “Performed your partner’s dick ever touch the opening of your own snatch rather than a condom?” When the victims constantly replied “no” for each and every work from genital sex within the eight-times several months, they certainly were coded due to the fact with had “no genital get in touch with instead of a great condom.” Analyses was indeed did as described more than, which have five types of the regularity out-of condom play with (100 percent without the vaginal get in touch with in place of an effective condom, 100 % with otherwise a not known frequency out of genital get in touch with instead good condom, and you can three groups less than 100 %, while the explained above).

Also, Cox proportional-risks models were utilized to decide chance items to the detection from event cervical squamous intraepithelial lesions in the eight months in advance of certain Pap test (based on a past observation that almost all sores can be found following experience illness 23 ). A great 51-go out slowdown prior to each head to try provided just like the 51 months is actually the quickest noticed interval between the date a female first got gender as well as the day away from recognition out of an incident lesion in this research. Research having such subjects was censored after the first detection of an instance lesion.


The latest suggest (±SD) age of the new 82 subjects at the subscription try 19.3±0.7 age. The fresh new subjects completed 709 check outs. The newest mean realize-up big date are 33.9±eleven.8 days, the new imply number of visits for each woman are 8.6±dos.9, therefore the median time taken between check outs is cuatro.step 1 months. Diary investigation were 90.eight per cent over, and condom investigation had been filed for the 99.step three percent regarding weeks one gender is actually said.

Desk dos

The latest twelve-month collective frequency out-of a primary HPV disease immediately after basic intercourse try 37.2 percent (95 % rely on interval, twenty seven.2 to forty-two.cuatro percent). All in all, 126 experience type of-specific infections were identified from inside the forty women after they basic had intercourse ( Table 2 ). Experience problems was in fact understood inside around three women in advance of it claimed that have sex for the first time, along with you to definitely confident to possess HPV form of 51, one to having HPV sorts of six, plus one for HPV products 40, 61, and 66. The fresh 24-day collective frequency from cervical squamous intraepithelial sores is 15.0 % (95 % confidence period, 8.3 to twenty-six.2 %).

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